The personal, social and economic effects of spinal cord injury (SCI) on the victims, their families and society at large are enormous. The most common SCI, resulting in paraplegia or quadriplegia, is the bruising of the myelin sheath of axons, followed by the progressive degeneration of neuronal tissue and glial scar and cyst formation1. In addition, axonal regeneration is repressed by inhibitory proteins such as Nogo and myelin-associated glycoprotein (MAG)2. With advances in the neurosciences and cell biology, there has been a major push to develop therapies that promote SCI repair. A successful strategy will most likely require a combination of biomolecular-, cellular- and biomaterial-based approaches. We have developed a range of biocompatible and biodegradable polyesterurethanes based on the well-defined PCL-PEG-PCL tri-block co-polymer building blocks and lysine-based polyisocyanates that can be used to form a 3-dimensional scaffold to bridge the SCI. The aim of the scaffold is to promote axonal growth, allow realignment of nerve tracts and provide mechanical protection to prevent ingress of scar tissue. We will report results on the biological compatibility including cytotoxicity and ES generated motor neuron (MN) cell adhesion of both bulk and electrospun polyurethane samples. The effect of the biomaterial on cell viability and proliferation of rat neural progenitors obtained from both the brain and spinal cord has also been investigated. Future experiments will involve in-vivo studies using the biomaterial in spinal cord injured rats.