Parkinson’s disease (PD) is an ageing-related neurodegenerative disorder that arises from interactions between environmental risk factors and genetic predispositions. This multifactorial aspect of the disease makes it difficult to find a therapy that benefits all patients.
Here, we used a cytological profiling of pure natural products against a panel of human olfactory neurosphere-derived (hONS) cells from PD patients and controls as a tool for identifying intrinsic cytological differences in PD and generating a response profile for each patient. The biological signature of each compound was determined through a series of cell-based assays reflecting known cellular pathways implicated in PD. We then clustered the compounds according to their biological activity profile. By exploring the response of patients to different drugs, we can gain a valued knowledge in the biology of PD.