Induced pluripotent stem cells, generated from Alzheimer’s disease patients or controls, were differentiated into neurons. While AD-iPSCs were indistinguishable from control-iPSCs, neuroprogenitors and neurons from AD patients showed increased susceptibility to cellular stresses, including inflammation and oxidative stress. Using this system scavenging drugs with neuroprotective properties were identified that prevent cellular stress-mediated death and degeneration of AD neurons.